Eastbound & Down

Danny McBride

Kenny Powers

Steve Little

Stevie Janowski

Ana de la Reguera

Vida

Ben Best

Clegg

Andy Daly

Terrence Cutler

Ike Barinholtz

Ivan Dochenko

John Hawkes

Dustin Powers

Jennifer Irwin

Cassie Powers

Katy Mixon

April Buchanon, April Buchanon (voice)

Rhoda Griffis

The Teacher

Chandler Massey

Pliny Caldwell

Simon Rhee

Sensei

Marlene Forte

Soledad

Joaquín Cosío

Hector

Jody Hill

Andrew, Pat Anderson's Sponsor

Deep Roy

Aaron

Eddie 'Piolin' Sotelo

Announcer

Efren Ramirez

Catuey

Marco Rodríguez

Roger Hernandez

Michael Peña

Mr. Cisneros

Joe Buck

Joe Buck

Gina Gershon

Realtor

Adam Scott

Pat Anderson

Sylvia Jefferies

Tracy

Shannon Eubanks

Donna Schaeffer

Jill Jane Clements

Shane's Mom

Megan Hayes

Gloria

Tim Ware

Shane's Dad

Alisa Harris

Brenda

Robin Mullins

Bobbi

Craig Robinson

Reg Mackworthy

Will Ferrell

Ashley Schaeffer

Jason Sudeikis

Cole Gerald, Shane Gerald, Shane Gerald / Cole Gerald

Don Johnson

Eduardo Sanchez

Erick Chavarria

Casper

Matthew McConaughey

Roy McDaniel

Seth Rogen

Texas Pitcher

Alex ter Avest

Andrea

Amber Brooke

Kate

John Cothran

Baseball Coach

Diva Tyler

Mamie

Justin Miles

Jacques

Lily Tomlin

Tammy Powers

Mandi Beers

Dottie

Cat Cora

Self

Marilyn Manson

Roller Rink Server

Jerry Minor

Jamie Laing

Michael Beasley

Jimmy Clay

Jillian Bell

Dixie

Samantha Beaulieu

Candy Cox

Sacha Baron Cohen

Ronnie Thelman

Bo Mitchell

Wayne

Elizabeth De Razzo

Maria

Ethan Alexander McGee

Dustin Jr.

Omar J. Dorsey

Dontel Benjamin

Tim Heidecker

Gene

Ken Marino

Guy Young

Jon Reep

Jed Forney

Mariano Mendoza

Rodney 'Hammer' Garcia

Alexander Skarsgård

Adult Toby Powers

Lindsay Lohan

Adult Shayna Powers

Collette Wolfe

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