Louie

Ashley Gerasimovich

Jane

Louis C.K.

Louie

Pamela Adlon

Pamela

Hadley Delany

Lilly

Ursula Parker

Jane

Ashlie Atkinson

Teacher

Nimo Gandhi

Taxi Driver #1

Chelsea Peretti

Date

Stephanie Berry

Principal

Parker Posey

Liz

David Lynch

Jack Dall

Chris Rock

Chris

Rick Crom

Rick

Robin Williams

Robin

Yvonne Strahovski

Blake

Sarah Baker

Vanessa

Devin Druid

Young Louie

Liam Broggy

Little Boy

Lynn Marocola

Knicks Fan (uncredited)

Jeremy Renner

Jeff Davis

Skipp Sudduth

Mr. Hoffman

Cory Nichols

Brad

Oscar Wahlberg

Danny

Sofia Hublitz

Danielle Hoffman

Gina Piersanti

Laurie

Sebastian Quinn

Concert Goer #1

Lily Peterson

Student

Liz Holtan

Ellen

Jay Russell

Jay

Nicole Ehinger

Young Tammy

Eddie Brill

Eddie

Ian Jarvis

Mediator

Jim Norton

Jim

William Stephenson

Bus Driver

Kathleen Butler

Naked Woman

Jay Oakerson

Bathroom Guy

Nilaja Sun

Woman on Phone

Elisabeth Hower

Trisha

Katy Grenfell

Parent #3

Meghan Rafferty

Parent #2

Laurine Towler

Parent #1

Robert Kelly

Bobby, Robbie

Cliff Samara

Patient

Marisa Vural

Waitress

Manny Siverio

Comedy Cellar Patron (uncredited)

Gregory Gunter

Dennis

Kate Blumberg

Martha

Hannibal Buress

Hannibal (uncredited), Hannibal

Dan Ziskie

Sheriff

Elizabeth Morton

Doreen

Stephen Badalamenti

TSA Agent

Christina Gausas

Ticket Agent

Todd Glass

Guy on Phone

David Patrick Kelly

Therapist, Therapist (uncredited)

Johnnie Mae

TSA Supervisor

Nancy Robinette

Woman Passenger

Matthew Broderick

Matthew Broderick

Hayley Podschun

Laurie

Gerry Vichi

Simon

Megan Hilty

Heckler

Sylvia Kauders

Woman

Clinton Lowe

Thug #2

Kenneth Maharaj

Cashier

Reza Salazar

Thug #1

Nancy Shayne

Teacher, Nancy

Amy Landecker

Sandra, Louie's Mom, Louie's Mother

Kurt Metzger

Kurt Metzger (uncredited)

Mary Louise Wilson

Dorethy

Ana Cruz Kayne

Jasmine

Josh Hamilton

Jeff

Tracee Chimo

Dog Pound Volunteer

Will Brill

Guy #1

Carla Corvo

College Girl #1

Sujoy De

Cashier

Christine Donlon

Jeff's Wife

Alicia Sable

College Girl #2

Cary Woodworth

Guy #2

Michael Drayer

Sean

Danny Burstein

Mike

Moisés Acevedo

Jock #4

Abraham Alvarez

Louie's Father

Gina Hernandez

High End Executive (uncredited)

Stephen Root

Dr. Hepa

Adepero Oduye

Tarese

Mando Alvarado

Manager

Bonita Elery

Tarese's Sister

Ann Dowd

Sister Carson

Tom Noonan

Dr. Haveford

Ricky Gervais

Dr. Ben

Bobby Cannavale

Chris

Stephen C. Bradbury

Dr. Drake

Kate Gilligan

Anchorwoman

Ted Alexandro

Flyer Comic

Ann Carr

Karen

Kelly Deadmon

Lisa

Nick Di Paolo

Nick

Godfrey

Godfrey

Rusty Schwimmer

Gretchen

Yul Vazquez

Pedro

Lucio Fernandez

Gypsy Cab Driver

Andrea Frierson

Nurse

Roderick Hill

Peter

Maria Dizzia

Delores

Munro M. Bonnell

Crazy Homeless Man

Liza Colón-Zayas

Miss Hernandez

Ryan Fitzsimmons

Man with Janice

Isaiah Stokes

Drugstore Employee

Peter Hans Benson

Ken

Donna Hanover

Gloria

Shafik N. Bahou

Shai

Todd Barry

Todd

Sam Haft

Young East Village Dude

Michael Torpey

Male Realtor

Teena Byrd

Bar Patron (uncredited)

Conner O'Malley

Young Louie