Victor and Valentino

Sean-Ryan Petersen

Boy (voice), Allen / Hair Dresser (voice), Bellhop #3 (voice), Valentino (voice), Additional Voices (voice), Stinky / Sheldon (voice)

Tony Plana

El Pintor (voice)

Fryda Wolff

Talon (voice)

Erica Lindbeck

Caw (voice)

Maria Bamford

Guadelupe (voice)

James Arnold Taylor

Chip (voice), Mustache (voice)

Olivia Trujillo

Matty (voice)

Kevin Michael Richardson

El Colorado (voice), Larry Ladron (voice)

Coati Mundi

Hector (voice)

Vanessa Marshall

Lechuza (voice), La Llorona (voice)

Max Mittelman

Additional Voices (voice), Fernando (voice)

Eric Bradley

El Silbon / Victor (whistling) (voice)

John DiMaggio

Garbage Man (voice), Alfonso (voice)

Dante Basco

Javier (voice)

Fred Tatasciore

Cuddles (voice), Chubacabra (voice), Mictlan (voice), Monster (voice), Botero (voice), Farmer (voice)

Spencer Rothbell

Miguelito (voice), Additional Voices (voice), Miguelito / Trader Josefino (voice)

Debi Derryberry

Cacao (voice), Additional Voices (voice)

Xolo Mariduena

Andres (voice), Additional Voices (voice)

Alan Ituriel

Black Hat (voice)

Todd Asayer

Dr. Flug (voice)

Erica Luttrell

Toni / Jaime (voice), Alma (voice), Alma Creator (voice), Additional Voices (voice), Alma / Rosanna (voice)

Carolina Ravassa

Ondina / Maya (voice), Anna (voice), Melodia (voice), Carla (voice), Camilla (voice), Tula's Mom (voice), Additional Voices (voice), Queenie (voice), Itzel (voice)

Eric Bauza

Rick / Richard (voice), Hype Man (voice), Shop Clerk (voice)

Parker Simmons

Team Captain (voice)

Montse Hernandez

Cristina (voice), Additional Voices (voice), Cristina / Cristina's Mom / Jenni (voice), Tula (voice), Jenni (voice), Tula / Fresa (voice)

Renée Victor

Delores (voice)

Dee Bradley Baker

Tzitzimime (voice), Camazotz / Big Camazotz, Tzitzimime / Quetzalcoatl (voice), Cammy (voice), Baby Camazotz (voice), Black Cadejo / White Cadejo (voice), Nagual (voice), Monster (voice), Additional Voices (voice), Ahuizotl / Sr. Roberto / Domingo (voice), Miguel (voice), Pete (voice), Baby Pepito (voice), Mictlantecuhtli (voice), Carmelita / Tzitzimime (voice)

Yuri Lowenthal

Moreno (voice), Baker / Flat Top (voice), Baker (voice)

Arnie Pantoja

Pilli (voice)

Christian Lanz

Achi / Oso (voice), Achi (voice), Tez / Golem / Guy 3 (voice), Huehue (voice), Tez / Jaguar Tez (voice), Tez (voice), Tez / Jaguar (voice), Achi / Dante (voice)

Daran Norris

Mic / Hun (voice), Mic (voice), Mic / Rupert (voice)

Francisco Ramos

Rey (voice), Waldo Pescado (voice), Rey / Man (voice)

George López

José Guadalupe Posada (voice)

Susana Ballesteros

La Catrina (voice)

Jason Hightower

Don Jalapeño / Li'l Smiley (voice), Don Jalapeño / Sr. Caido / Dog (voice), Don Jalapeño (voice), Don Jalapeño / Pete (voice)

Tom Kenny

Guillermo (voice), Additional Voices (voice), Guillermo / Boring Guy (voice)

Keith Ferguson

Teo (voice)

Cristina Milizia

Isabella (voice), Isabella / Girl (voice), Charlene / Mary (voice), Charlene / Reynalda (voice), Reynalda (voice), Charlene / Actress (voice), Charlene / Reynalda / Huitzi (voice), Huitzi (voice), Charlene / Isabella / Reynalda (voice), Additional Voices (voice), Reynalda / Sweetie Poo / Pinky (voice), Isabella / Hotel Guest (voice), Charlene / Isabella (voice), Charlene / Reynalda / Isabella / Huitzi (voice), Charlene (voice), Reynalda / Isabella (voice), Isabella / Huitzi (voice), Charlene / Tlaltecuhtli (voice)

Felipe Esparza

El Bigote (voice)

Laura Patalano

Grandma Chata / Big Mama (voice), Grandma Chata (voice)

Miguel Ángel López Díaz

Rey Misterio (voice)

Cristina Valenzuela

Xochi (voice), Additional Voices (voice), Xochi / Lady 1 (voice), Xochi / Gal 2 (voice), Xochi / Coyolxauhqui (voice)

Nathalia Hencker

Reyna (voice)

Oscar Montoya

Ramon (voice)

Frankie Quinones

Maria Teresa / Clerkman (voice), Nacho (voice), Maria Teresa (voice)

Eric Lopez

Gustavo (voice), Gustavo / Emilio (voice)

Carlos Alazraqui

Miguelito (voice), Jaguar Patrol (voice), Jaguar Patrol / Teacher (voice), Additional Voices (voice), Miguelito / Jaguar Patrol (voice), Esteban (voice), Miguelito / Gondolier (voice), Miguelito / Mailman (voice), Ticket Guy / Manager / Bellhop #1 (voice), Miguelito / La Pulga (voice)

Danny Trejo

Paco (voice), The Cupcake Man (voice)

Alex Cazares

Amabel (voice)

Elisabeth Garcia

Mariachi (voice)

Carl Jones

Cacao / Additional Voices (voice)