Pepper Ann

Kathleen Wilhoite

Pepper Ann (voice)

Danny Cooksey

Milo (voice)

Clea Lewis

Nicky (voice)

Clea Lewis

Nicky (voice)

April Winchell

Mom (voice)

Kimmy Robertson

Gwen Mezzrow, Gwen Mezzrow (voice)

Luke Perry

Stewart Walldinger (voice)

Pamela Adlon

Goose O'Shaunassy (voice), Moose (voice), Moose Pearson (voice)

Don Adams

Principal Hickey, Principal Herbert Hickey (voice), Principal Hickey (voice)

Hadley Kay

Alex Trebek

Lauren Tom

Nicole Sullivan

Tundra Woman (voice)

Evel Knievel

Mark Hamill

Jodi Benson

Amber O'Malley (voice)

Isabel Sanford

Bernice (voice)

Don Lake

Mr. Sherman Finky / Butler (voice), Mr. Sherman Finky (voice)

Kathy Najimy

Coach Doogan (voice)

Paddi Edwards

Vera Groober-Schwartz (voice), Vera Groober-Schwarz (voice)

Jason Marsden

Prep School Guy (voice)

Candi Milo

Constance Goldman (voice), Constance Goldman / Deeana / Biana (voice), Rose (voice)

Wallace Langham

Wayne Macabre (voice; uncredited)

Hedy Burress

Effie Shrugg (voice)

Jess Harnell

Abe (voice), Additional Voices (voice), Male Scientist / Nigel / Mailman (voice)

Jeff Bennett

Dieter Liederhosen (voice), Dieter Liederhosen / Emit Swink / Shelf McClain (voice), Larry / Additional Voices (voice), Craig Bean / Pink-Eye Pete / Additional Voices (voice), Craig Bean / Ned Diggity (voice), Christmas Tree / Grandpa Leo / Pink-Eye Pete (voice), Dieter Liederhosen / Shelf McClain (voice), Grandpa Leo / Additional Voices (voice), Craig Bean / Dieter Liederhosen / Vittorio (voice), Craig Bean / Dieter Liederhosen / Additional Voices (voice), J.B. / Additional Voices (voice), Noah / Additional Voices (voice), Dieter Liederhosen / Craig Bean / Shelf McClain (voice), Craig Bean / Ned Diggity / Grandpa Leo (voice), Dieter Liederhosen / Pink-Eye Pete (voice), Craig Bean / Dieter Liederhosen / Bob / Additional Voices (voices), Craig Bean (voice)

Shaun Fleming

Cookie (voice)

Jenna Von Oÿ

Trinket (voice), Trinket St. Blair (voice)

Tara Strong

Brenda / Female Scientist (voice), Brenda (voice)

Jim Cummings

Mr. Roland Carter / Additional Voices (voice), Mr. Roland Carter (voice)

Max Brooks

Worried Executive #1 (voice)

Phil LaMarr

Stubborn Executive / Hippie Guy (voice)

Tino Insana

Uncle Jo Jo (voice), Uncle Jojo (voice), Additional Voices (voice), Uncle Jojo / Earl (voice)

Susan Tolsky

Aunt Janie Diggety (voice), Aunt Janie (voice), Aunt Janie Diggety / Aunt Lanie (voice)

Cam Clarke

Stewart Walldinger (voice)

Cree Summer

Tessa James / Vanessa James / Additional Voices (voice) (as Cree Summer-Francks), Crying Girl (voice), Tessa and Vanessa James / Additional Voices (voice), Tessa & Vanessa James (voice), Tessa and Vanessa James (voice)

Bebe Neuwirth

Ms. Bladdar (voice), Ms. Bronte Bladdar (voice)

Kenn Michael

Malik / Lamar Abu Dabe (voice), Lamar Abudabe (voice), Lamar Abu Dabe (voice)

Kath Soucie

Cissy Rooney / Supermodel Mindy (voice), Mean Girl (voice), Cissy Rooney (voice), Cissy Rooney / Mrs. Little / Grammie Pearson (voice), Cissy Rooney / Additional Voices (voice), Mail Lady (voice), Additional Voices (voice)

Maurice LaMarche

Chuck Pearson / Frankie / Uncle Harry (voice), Chuck Pearson / Menorah / Colonel Delaney (voice), Chuck Pearson / Jeweler (voice)

Max Casella

Additional Voices (voice)

Julia Sweeney

Ms. Sneed (voice)

Karen Duffy

Sketch (voice)

Meredith Scott Lynn

Poison (voice)

Brittany Murphy

Tank (voice)

Julia Duffy

Aunt Fanny (voice)

Francesca Marie Smith

Damiana (voice)