Pepper Ann

Kathleen Wilhoite

Pepper Ann (voice)

Danny Cooksey

Milo (voice)

Clea Lewis

Nicky (voice)

April Winchell

Mom (voice)

Kimmy Robertson

Gwen Mezzrow

Luke Perry

Stewart Walldinger (voice)

Don Adams

Principal Hickey (voice), Principal Hickey

Alex Trebek

Lauren Tom

Nicole Sullivan

Tundra Woman (voice)

Evel Knievel

Mark Hamill

Jodi Benson

Amber O'Malley (voice)

Isabel Sanford

Bernice (voice)

Tara Strong

Brenda / Female Scientist (voice)

Paddi Edwards

Vera Groober-Schwartz (voice)

Tino Insana

Uncle Jo Jo (voice)

Jess Harnell

Male Scientist / Nigel / Mailman (voice), Abe (voice)

Kathy Najimy

Coach Doogan (voice)

Jenna von Oy

Trinket (voice)

Bebe Neuwirth

Ms. Bladdar (voice)

Jason Marsden

Prep School Guy (voice)

Don Lake

Mr. Sherman Finky / Butler (voice), Mr. Sherman Finky (voice)

Jeff Bennett

Craig Bean (voice), Dieter Liederhosen / Pink-Eye Pete (voice), Noah / Additional Voices (voice), Dieter Liederhosen / Craig Bean / Shelf McClain (voice), J.B. / Additional Voices (voice), Dieter Liederhosen / Emit Swink / Shelf McClain (voice), Dieter Liederhosen (voice), Larry / Additional Voices (voice), Dieter Liederhosen / Shelf McClain (voice), Grandpa Leo / Additional Voices (voice), Craig Bean / Dieter Liederhosen / Vittorio (voice)

Candi Milo

Constance Goldman (voice), Constance Goldman / Deeana / Biana (voice), Rose (voice)

Pamela Adlon

Moose Pearson / Goose O'Shaunassy (voice), Moose Pearson (voice)

Wallace Langham

Wayne Macabre (voice; uncredited)

Hedy Burress

Effie Shrugg (voice)

Jim Cummings

Mr. Roland Carter (voice)

Susan Tolsky

Aunt Janie Diggety / Aunt Lanie (voice), Aunt Janie Diggety (voice)

Shaun Fleming

Cookie (voice)

Cree Summer

Crying Girl (voice), Tessa James / Vanessa James (voice)

Kenn Michael

Lamar Abudabe (voice), Lamar Abu Dabe (voice)

Maurice LaMarche

Chuck Pearson / Jeweler (voice)

Kath Soucie

Mail Lady (voice), Cissy Rooney / Supermodel Mindy (voice), Mean Girl (voice)

Max Brooks

Worried Executive #1 (voice)

Phil LaMarr

Stubborn Executive / Hippie Guy (voice)

Cam Clarke

Stewart Walldinger (voice)