Big Mouth

Nick Kroll

Nick Birch / Maury the Hormone Monster / Coach Steve (voice)

John Mulaney

Andrew Glouberman (voice)

Jessi Klein

Jessi Glaser (voice)

Jason Mantzoukas

Jay Bilzerian (voice)

Maya Rudolph

Diane Birch / Constance the Hormone Monstress (voice)

Fred Armisen

Elliot Birch (voice)

Jordan Peele

Ghost of Duke Ellington (voice)

Pamela Adlon

Sonya the Lovebug (voice)

Andrew Rannells

Matthew MacDell (voice), Matthew (voice)

Ayo Edebiri

Missy Foreman-Greenwald / Mosaic Missy (voice), Missy Foreman-Greenwald (voice)

Jenny Slate

Missy Foreman-Greenwald (voice)

Jessica Chaffin

Shannon Glaser (voice), Shannon Glaser / Grace / Intellect Sphinx (voice)

Brandon Kyle Goodman

Walter the Lovebug (voice), Walter (voice)

Jon Hamm

Scallops (voice)

Kristen Bell

Uninterested Girl (voice), Pam the Pillow (voice)

Jon Gabrus

Movie Theater Customer (voice)

Anna Graves

Mrs. Albert (voice)

Nasim Pedrad

Fatima (voice)

Mae Whitman

Tallulah Levine (voice)

Philip Quinaz

Tanya Alvarez (voice)

John Gemberling

Tyler the Hormone Monster / Dot #1 (voice), Tyler the Hormone Monster (voice), Security Guard / Bus Driver's Son (voice)

Harvey Fierstein

Older Guy Town Resident (voice)

Jerry Minor

Man #3 / Singing Fish (voice)

Joe Wengert

Caleb / Rewind Shirt Kid / Go-Gurt Burglar (voice), Caleb / Go-Gurt Burglar (voice), Steven Tyler Glade Plug-In / Zombie (voice), Mr. Albert (voice), Caleb / Lump Humpman (voice), Caleb / Go-Gurt Thief / Teacher (voice), Caleb / Pornscape Residents (voice), Stan the Hormone Monster / Ambition Gremlin (voice), Caleb (voice), Caleb / Dot #3 / Leore Paulblart (voice), Teacher (voice), Caleb / IUD (voice)

Piotr Michael

Siamese Twin #2 (voice)

Craig Robinson

End Credits Singer (voice), (voice), Pubic Hair #2 (voice)

Andy Daly

Dr. Wendy Engle / Motel Pillow #1 (voice), Ghost of Harry Houdini (voice), Dr. Wendy Engle (voice)

Gil Ozeri

(voice), Wiggles (voice), The Ponytail Killer / Pornscape Residents (voice), Man #1 / Dot #2 (voice), Jew Fishman (voice), Brad (voice)

Martin Short

Gordie (voice)

Carlos Alazraqui

Gustavo (voice)

David Cross

Skip Glouberman (voice)

Carol Kane

Menopause Banshee / Old Woman (voice)

Zach Woods

Daniel (voice), Sock (voice)

Michaela Watkins

Cantor Dina Reznick (voice)

Julie Klausner

Cherry Marashina (voice)

Neil Casey

(voice), Lars / Detective Dumont / Pornscape Residents (voice), Detective Dumont (voice), Lars / Jew Penis (voice), Lars / Boy (voice), Lars / Detective Dumont (voice), Lars (voice), Detective Dumont / D.N. Ape (voice), Lars / Rewind Shirt Kid (voice), Detective Dumont / Lars (voice)

Tawny Newsome

(voice)

Chris Redd

(voice)

Retta

Duke's Mother (voice)

Fran Gillespie

(voice), Maddie the American Girl Doll / Choir Girl (voice), Samira (voice), Girl (voice)

Wanda Sykes

Ghost of Harriet Tubman (voice)

Jaboukie Young-White

(voice)

Rosa Salazar

Ms. Benitez (voice)

Chelsea Peretti

Cellsea (voice), Monica Foreman-Greenwald (voice), Diaphragm (voice)

Rob Riggle

Sgt. Adderall (voice)

Bobby Berk

Bobby Berk (voice)

Karamo Brown

Karamo Brown (voice)

Bobby Cannavale

Gavin (voice), Gavin the Hormone Monster (voice), Nick's Agent (voice)

Nathan Fillion

Nathan Fillion (voice)

Tan France

Tan France (voice)

Rob Huebel

Mr. Lizer (voice)

Paula Pell

Barbara Glouberman / Lola's Couch Pillow (voice), Barbara Glouberman / Bubbe (voice), (voice), Barbara Glouberman (voice)

Antoni Porowski

Antoni Porowski (voice)

Jonathan Van Ness

Jonathan Van Ness (voice)

Jak Knight

DeVon, DeVon / Gina's Brother #2 (voice), Tall Guy (voice), DeVon (voice)

Natasha Lyonne

Suzette (voice)

Anna Konkle

Izzy (voice)

Gary Cole

Andrew's Father (voice), Edward MacDell (voice), Matthew's Father (voice)

Maya Erskine

Misha (voice)

David Thewlis

Shame Wizard (voice)

John Oliver

Harry (voice)

Kat Dennings

Leah Birch / Lorraine the Hormone Monstress (voice), Leah Birch (voice)

Seth Rogen

Seth Goldberg (voice)

Alia Shawkat

Roland (voice)

Josie Totah

Natalie (voice)

Gina Rodriguez

Gina Alvarez (voice), Gina Alvarez / Gina Parrot (voice)

Paul Scheer

Kurt Bilzerian (voice)

Paul Giamatti

Andrew’s Shit (voice)

Julie White

Kimberly (voice), Kimberly MacDell (voice)

Sterling K. Brown

Michael Angelo (voice)

Jon Daly

Garrison Keillor / Magician #1 (voice), Judd Birch (voice), Judd Birch / Pumbaa (voice)

Ali Wong

Ali (voice)

Seth Morris

Ninth Grader (voice), (voice), Greg Glaser (voice)

Maria Bamford

Tito the Anxiety Mosquito (voice)

Thandiwe Newton

Mona (voice)

June Diane Raphael

Devin (voice)

Heather Lawless

Jenna Bilzerian (voice)

Kristen Wiig

Jessi's Vagina (voice)

Jean Smart

Depression Kitty (voice)

Zachary Quinto

Aiden (voice)

Adam Scott

Mr. Keating (voice)

Hugh Jackman

himself (voice)

Kumail Nanjiani

himself (voice)

Jemaine Clement

Simon Sex (voice)

Kristen Schaal

Bernie Sanders (voice)

Mark Duplass

Val Bilzerian (voice)

Joel Kim Booster

Charles Lu (voice)

Quinta Brunson

Quinta (voice), Girl (voice)

Judd Hirsch

Lewis Glouberman (voice)

Somali Rose

Missy’s Overalls

Jack McBrayer

Pubic Hair #1 (voice)

Beck Bennett

Owen (voice)

Richard Kind

Marty Glouberman (voice)

Lena Waithe

Lena (voice)

Lupita Nyong'o

Asha (voice)

Miranda Tapsell

Kara (voice)

Lin-Manuel Miranda

Puerto Rican Pubic Hair (voice)

Megan Thee Stallion

Megan the(e?) Hormone Monstress (voice)

Randall Park

Pete Doheny (voice)

Stephanie Beatriz

Lulu (voice)

Maitreyi Ramakrishnan

Marissa (voice)

Ava Lalezarzadeh

Nazanin (voice)

Don Cheadle

Don Cheadle (voice)

Billy Porter

Ocean (voice)

Padma Lakshmi

Priya (voice)

Chloe Fineman

Leah Birch (voice)

Ayden Mayeri

Gabrielle / Freshman (voice), Gabrielle / Mellon Ball / Honeydew (voice), Gabrielle (voice), Gabrielle / Sad Boy #2 (voice)

Patrick Page

Dread (voice)

Aidy Bryant

Emmy (voice)

Keke Palmer

Rochelle the Hate Worm (voice)

Zach Galifianakis

Gratitoad (voice)

Jeff Goldblum

The Apple Brooch

Steve Buscemi

Whitmer Thomas

Rosie Perez

Petra (voice)

Skyla I'Lece

Mitra Jouhari

Larry Owens

Holly Hunter

James III

Juliet Mills

Cynthia Erivo

Andrew Goldberg