Your Friendly Neighborhood Spider-Man

Hudson Thames

Peter Parker / Spider-Man (voice)

Colman Domingo

Norman Osborn (voice)

Eugene Byrd

Lonnie Lincoln (voice)

Grace Song

Nico Minoru (voice)

Zeno Robinson

Harry Osborn (voice), Mr. Campbell (voice)

Kari Wahlgren

May Parker (voice), Roxanna Volkov (voice), Mrs. Eberhardt (voice)

Charlie Cox

Daredevil (voice)

Robin Atkin Downes

Doctor Strange (voice)

Cathy Ang

Pearl Pangan (voice)

Ogie Banks

Pizza Shop Owner (voice)

Andre Robinson

Additional Voices (voice)

Arthur Ortiz

Additional Voices (voice)

Diamond White

Additional Voices (voice)

Griffin Puatu

Additional Voices (voice)

Isabella Acres

Additional Voices (voice)

Noah Kaye Bentley

Additional Voices (voice)

Oscar Camacho

Additional Voices (voice)

ViviAnn Yee

Additional Voices (voice)

Terri Douglas

Additional Voices (voice)

Aleks Le

Amadeus Cho (voice)

Paul F. Tompkins

Bentley Wittman (voice)

Jake Green

Butane (voice)

Erica Luttrell

Mrs. Lincoln (voice), Emma (voice), Asha (voice), Emma / Mrs. Lincoln (voice)

Phil LaMarr

Mr. Taylor (voice), Mr. Lincoln (voice), Mr. Taylor / Mr. Lincoln (voice)

Anairis Quinones

Carmilla Black (voice), Maria Vasquez (voice)

Kellen Goff

Vincent Patillo (voice), Symbiotic Alien (voice), Vincent Patilio (voice)

Ettore Ewen

Bulldozer (voice)

Alex Désert

Grift (voice)

Roger Craig Smith

Dimitri Smerdyakov (voice), James 'Speed Demon' Sanders (voice), Dmitri Smerdyakov / Chameleon (voice), Coach Grayfield (voice), Dmitri Smerdyakov (voice)

Leilani Barrett

Big Donavan (voice), Big Donovan (voice)

Sarah Natochenny

Mila Masaryk (voice)

Zehra Fazal

Hot Rod (voice), Dr. Connors (voice), Dr. Connors (voice), Susan O'Harra (voice)

Jonathan Medina

Mac Gargan (voice)

Travis Willingham

Thaddeus Ross (voice), Mikhail Sytsevich (voice)

Hugh Dancy

Otto Octavius (voice)

Zach Cherry

Klev (voice)

Mick Wingert

Tony Stark / Iron Man (voice)

Josh Keaton

Richard Parker (voice)